Z701853 Chemical Structure

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1mg
$ 50.000.0
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10mg
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$ 95.000.0
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Z701853

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Product Description

Catalogue NumberZ701853
Chemical Namezm447439
SynonymsZM 447439; N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide;
CAS Number331771-20-1
Molecular FormulaC₂₉H₃₁N₅O₄
Molecular Weight513.59
ApplicationsIt is a potent and selective inhibitor of Aurora B kinase. Cells treated with ZM-447439 progress through interphase, enter mitosis and assemble bipolar spindles but chromosome alignment, segregation and cytokinesis all fail. It induces apoptosos in Hep2 cancer cells and in acute myeloid leukemia cell lines but its propensity to induce polyploidy does not inevitably result in apoptosis.
ReferencesDitchfield, C., et al.: J. Cell Biol., 161, 267 (2003), Long, Z.J., et al.: J. Cell Cycle, 7, 1473 (2008), Walsby, E., et al.: Haematologica, 93, 662 (2008),