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Pack Size Quantity Price (USD) Sub Total
1mg
$ 50.00 0.0
2mg
$ 60.00 0.0
10mg
$ 85.00 0.0
Exact Weight Packaging
$ 75.00 / Vial 0.0
Total $ 0.0
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Product Description

Catalogue Number: Z701853
Chemical Name: zm447439
Synonyms: ZM 447439; N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide;
CAS Number: 331771-20-1
Molecular Formula: C₂₉H₃₁N₅O₄
Molecular Weight: 513.59
Applications: It is a potent and selective inhibitor of Aurora B kinase. Cells treated with ZM-447439 progress through interphase, enter mitosis and assemble bipolar spindles but chromosome alignment, segregation and cytokinesis all fail. It induces apoptosos in Hep2 cancer cells and in acute myeloid leukemia cell lines but its propensity to induce polyploidy does not inevitably result in apoptosis.
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