Z623505 Chemical Structure

All Products are stable to be shipped at room temperature, unless otherwise specified.
Pack SizeQuantityPrice (USD)Sub Total
2.5mg
$ 55.000.0
5mg
$ 80.000.0
25mg
$ 230.000.0
250mg
$ 1130.000.0
Exact Weight Packaging
$ 145.000.0
Total$ 0.0
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Z623505

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Product Description

Catalogue NumberZ623505
Chemical NameZoledronic acid
SynonymsP,P'-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-phosphonic Acid;
CAS Number118072-93-8
Molecular FormulaC₅H₁₀N₂O₇P₂
AppearanceWhite to Off-White Solid
Melting Point>210°C (Subl.)
Molecular Weight272.09
Storage4°C, Hygroscopic
SolubilityWater (Slightly)
Stabilityextremely hygroscopic, Extremely Hygroscopic
Category Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsZoledronic acid induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho.
ReferencesJagdev, S., et al.: Br. J. Cancer, 84, 1126 (2001); Viereck, V., et al.: Biochem. Biophys. Res. Commun., 291, 680-686.Croucher. P., et al.: J. Bone Miner. Res., 2003, 18(3), 482-492.