All Products are stable to be shipped at room temperature, unless otherwise specified.
| Pack Size | Quantity | Price (USD) | Sub Total |
|---|---|---|---|
| 1mg | $ 50.00 | 0.0 | |
| 2mg | $ 60.00 | 0.0 | |
| 10mg | $ 85.00 | 0.0 | |
| 25mg | $ 160.00 | 0.0 | |
| 50mg | $ 295.00 | 0.0 | |
| 100mg | $ 560.00 | 0.0 | |
| Exact Weight Packaging | $ 145.00 | 0.0 | |
| Total | $ 0.0 | ||
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- Ships On : 4/13/2023
Z487000
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Product Description
| Catalogue Number | Z487000 |
| Chemical Name | ZM 447439 |
| Synonyms | N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide; |
| CAS Number | 331771-20-1 |
| Molecular Formula | C29H31N5O4 |
| Appearance | Pale Yellow Solid |
| Melting Point | >104°C |
| Molecular Weight | 513.59 |
| Storage | Refrigerator |
| Solubility | DMSO, Methanol |
| Category | Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| Applications | It is a potent and selective inhibitor of Aurora B kinase. Cells treated with ZM-447439 progress through interphase, enter mitosis and assemble bipolar spindles but chromosome alignment, segregation and cytokinesis all fail. It induces apoptosos in Hep2 cancer cells and in acute myeloid leukemia cell lines but its propensity to induce polyploidy does not inevitably result in apoptosis. |
| References | Ditchfield, C., et al.: J. Cell Biol., 161, 267 (2003), Long, Z.J., et al.: J. Cell Cycle, 7, 1473 (2008), Walsby, E., et al.: Haematologica, 93, 662 (2008), |