Z487000 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
10mg
$ 98.000.0
Exact Weight Packaging
$ 145.000.0
Total$ 0.0
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  • Inventory Status : Pending QC
  • Ships On : 10/13/2023
Z487000

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Product Description

Catalogue NumberZ487000
Chemical NameZM 447439
SynonymsN-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide;
CAS Number331771-20-1
Molecular FormulaC₂₉H₃₁N₅O₄
AppearancePale Yellow Solid
Melting Point>104°C
Molecular Weight513.59
Storage4°C
SolubilityDMSO, Methanol
Category Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsIt is a potent and selective inhibitor of Aurora B kinase. Cells treated with ZM-447439 progress through interphase, enter mitosis and assemble bipolar spindles but chromosome alignment, segregation and cytokinesis all fail. It induces apoptosos in Hep2 cancer cells and in acute myeloid leukemia cell lines but its propensity to induce polyploidy does not inevitably result in apoptosis.
ReferencesDitchfield, C., et al.: J. Cell Biol., 161, 267 (2003), Long, Z.J., et al.: J. Cell Cycle, 7, 1473 (2008), Walsby, E., et al.: Haematologica, 93, 662 (2008),