Z486500 Chemical Structure

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Product Description

Catalogue NumberZ486500
Chemical NameZM 213689 Disodium Salt (Meropenem impurity)(Mixture of double bond isomers)
Synonyms(αS,2S,3R,4S)-5-Carboxy-4-[[(3S,5S)-5-[(dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-3,4-dihydro-α-[(1R)-hydroxyethyl]-3-methyl-2H-pyrrole-2-acetic Acid Disodium Salt; H 4295 Disodium Salt; ICI 213689 Disodium Salt; UK 1a Disodium Salt;
Alternate CAS #124190-28-9
Molecular FormulaC₁₇H₂₅N₃Na₂O₆S
AppearanceLight Orange to Brown Solid
Melting Point>161°C (dec.)
Molecular Weight445.44
Storage-20°C, Hygroscopic
SolubilityMethanol (Slightly), Water (Sparingly)
StabilityHygroscopic
Category Standards; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsThe major metabolite of Meropenem (M225620) - a carbapenem antibiotic - in plasma and urine. This metabolite existed as a mixture of 1-pyrroline and its 2-pyrroline isomer, and the coexistence of the two isomers at equilibrium in aqueous solutions was observed by NMR.
ReferencesTakeuchi, Y., et al.: J. Antibiotics, 46, 827 (1993), Wiseman, L., et al.: Drugs, 50, 73 (1995), Valtonen, M., et al.: J. Antimicrob. Chemother., 45, 701