Catalogue number: X746250
Chemical name: XL518
Synonyms: [3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl][3-hydroxy-3-[(2S)-2-piperidinyl]-1-azetidinyl]methanone; GDC 0973; XL 518;
CAS Number: 934660-93-2
Possible CAS #: NA
Molecular form.: C₂₁H₂₁F₃IN₃O₂
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 531.31
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Protein Kinase Inhibitors and Activators,
Boiling Point: No Data Available
Applications: A potent, selective, orally bioavailable inhibitor of MEK1, a component of the RAS/RAF/MEK/ERK pathway. It inhibits proliferation and stimulates apoptosis in a variety of human tumor cell lines. In preclinical xenograft models, oral administration of XL518 results in sustained inhibition of pERK in tumor tissue, but not brain tissue, leading to tumor growth inhibition and regression at well tolerated doses.
Dangerous Goods Info: NA
Peer Review Product Citations:
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  Pack size Price(USD)
1mg $95.00
10mg $275.00
100mg $1275.00
  Pack size Price(USD)
5mg $150.00
50mg $875.00

Exact Weight Packaging ($75(USD) / Vial)
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