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Product Description

Catalogue Number: V500000
Chemical Name: O2-Vinyl 1-(Pyrrolidin-1-yl)diazen-1-ium-1,2-diolate
Synonyms: 1-(Ethenyloxy)-3-(2-pyrrolidinyl)-3-(5-pyrrolidinyl)-1-triazenamine 2-oxide; 1-[(Ethenyloxy)-NNO-azoxy]-pyrrolidine; V-PYRRO/NO;
CAS Number: 179344-98-0
Molecular Formula: C₆H₁₁N₃O₂
Appearance: Pale Yellow Oil
Molecular Weight: 157.17
Solubility: Ethanol
Stability: Store in Freezer (> 1 year at -20°)
Category: Heterocycles, Nitric Oxide Reagents
Applications: V-PYRRO/NO is a metabolically activated nitric oxide (NO) donor drug that can be used to selectively target NO delivery to the liver. The compound is metabolized by the liver, and spontaneously decomposes with a half-life of 3 seconds, liberating NO. Infusion of 30nmol/kg of V-PYRRO/NO in rats causes only a slight drop in blood pressure. At concentrations >100ug, V-PYRRO/NO increases hepatocyte viability against TNF-a-induced apoptosis by approximately 2-fold compared to cells not treated with this compound. UV/Vis: lmax: 267nm e: 9,700
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