TRC | Details of CAS = 1215100-18-7, ChemicalName = Vandetanib-d4, synonym = N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[[1-methyl-4-(piperidinyl-d4)]methoxy]-4-quinazolinamine; 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[[1-methyl(piperidin-4-yl)-d4]methoxy]quinazoline; ZD 6474-d4; Zactima-d4;, MolFormula = C₂₂H₂₀D₄BrFN₄O₂

Catalogue Number:	V097102
Chemical Name:	Vandetanib-d4
Synonyms:	N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[[1-methyl-4-(piperidinyl-d4)]methoxy]-4-quinazolinamine; 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[[1-methyl(piperidin-4-yl)-d4]methoxy]quinazoline; ZD 6474-d4; Zactima-d4;
CAS Number:	1215100-18-7
Alternate CAS #:	Unlabelled: 443913-73-3
Molecular Formula:	C₂₂H₂₀D₄BrFN₄O₂
Molecular Weight:	479.38
Category:	Aromatics, Heterocycles, Inhibitors, Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals,
Applications:	A labelled Vandetanib; a once-daily oral inhibitor of vascular endothelial growth factor receptor-2 and epidermal growth factor receptor kinase activity. The activity of vandetanib plus docetaxel was assessed in patients with previously treated non-small-cell lung cancer (NSCLC).
References:	Bruns, C., et al.: Clin. Cancer Res., 6, 1936 (2000); Hennequin, L., et al.: J. Med. Chem., 45, 1300 (2002); Park, M., et al.: J. Biol. Chem., 278, 50624 (2003); Arao, T., et al.: Cancer Res., 64, 9101 (2004); Prueitt, R., et al.: Int. J. Cancer, 120, 796 (2007);

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