Catalogue number: T686000
Chemical name: N-α-Tosyl-L-phenylalanylchloromethane
Synonyms: L-1-Chloro-3-tosylamidyl-4-phenyl-2-butanone; L-1-Chloro-4-phenyl-3-p-tolylsulfonamidobutan-2-one; L-1-Chloro-4-phenyl-3-toluene-p-sulfonamido-2-butanone; L-1-Tosylamide-2-phenylethylchloromethyl Ketone; L-1-Tosylamido-2-phenylethyl Chloromethyl Ketone; L-Tolylsulfonylphenylalanyl Chloromethyl Ketone; N-(p-Toluenesulfonyl)-L-phenylalanylchloromethane; N-Tosyl-L-phenylalaninechloromethane; N-Tosyl-L-phenylalanyl Chloromethyl Ketone; N-Tosyl-L-phenylalanylchloromethane; N-Tosylphenylalanine Chloromethyl Ketone; N-α-Tosyl-L-phenylalanylchloromethane; Nα-Tosyl-L-phenylalanine Chloromethyl Ketone; TPCK; Tosylphenylalanine Chloromethyl Ketone; Tosylphenylalanylchloromethane; α-N-Tosyl-L-phenylalanine Chloromethyl Ketone
CAS Number: 402-71-1
Possible CAS #: NA
Molecular form.: C₁₇H₁₈ClNO₃S
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 351.85
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Amino Acids & Derivatives, Apoptosis, Aromatics, Inhibitors
Boiling Point: No Data Available
Applications: N-α-Tosyl-L-phenylalanylchloromethane is a proteinase inhibitors with apoptotic function. Studies have shown that it induces caspase-dependent apoptosis in Epstein-Barr virus (EBV)-transformed human B cell lines with release of pro-apoptotic proteins from mitochondria. It also results in down-regulation of the anti-apoptotic proteins and caspase-dependent cleavage of two anti-apoptotic proteins. It promotes dephosphorylation of p53 on serine residues.
Dangerous Goods Info: NA
Peer Review Product Citations:
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