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| Pack Size | Quantity | Price (USD) | Sub Total |
|---|---|---|---|
| 25mg | $ 4500.00 | 0.0 | |
| Exact Weight Packaging | $ 145.00 | 0.0 | |
| Total | $ 0.0 | ||
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T010012
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Product Description
| Catalogue Number | T010012 |
| Chemical Name | Taxol D-d7 |
| Synonyms | (αR,βS)-α-Hydroxy-β-[(1-oxobutyl)amino]benzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12bBbis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester-d7; [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-α-Hydroxy-β-[(1-oxobutyl)amino]benzenepropanoic Acid 6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester-d7; 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete Benzenepropanoic Acid Deriv.-d7; Taxcultine-d7; |
| Alternate CAS # | Unlabelled: 153415-46-4 |
| Molecular Formula | C₄₄H₄₆D₇NO₁₄ |
| Molecular Weight | 826.93 |
| Category | Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites; |
| Applications | Taxol D-d7 is the isotope labelled analog of Taxol D (T010010); an impurity of Paclitaxel (P132500) which is an antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. |
| References | Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984); Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984); Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995); Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002); Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004) |