Tamoxifen


Catalogue Number: T006000
Chemical Name: Tamoxifen
Synonyms: (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine; ICI 47699; Mammaton; Novaldex; Tamoxifen; Z-Tamoxifen; trans-Tamoxifen;
CAS Number: 10540-29-1
Molecular Formula: C₂₆H₂₉NO
Appearance: White to Off-White Solid
Melting Point: >92°C (dec.)
Molecular Weight: 371.52
Storage: Amber Vial, -20°C Freezer
Solubility: Chloroform (Sparingly), Methanol (Slightly)
Stability: Light Sensitive
Category: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals, Protein Kinase Inhibitors and Activators,
Applications: Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells. Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.
References:

All Products are stable to be shipped at room temperature, unless otherwise specified.
MSDS: T006000.pdf
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  Pack size Price(USD)
500mg $45.00
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2.5g $120.00
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25g $250.00
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1g $65.00
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10g $150.00
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Exact Weight Packaging ($75(USD) / Vial)
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Inventory Status:   In Stock




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