R701010 Chemical Structure

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Product Description

Catalogue NumberR701010
Chemical NameRTI-55 Hydrochloride
Synonyms(1R,2S,3S,5S)-3-(4-Iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic Acid Methyl Ester Hydrochloride; [1R-(exo,exo)]-3-(4-Iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic Acid Methyl Ester Hydrochloride; RTI 4229-98 Hydrochloride; β-CIT Hydrochloride;
CAS Number141899-24-3
Alternate CAS #freebase: 135416-43-2
Molecular FormulaC₁₆H₂₁ClINO₂
AppearanceOff-White to Pale Yellow Solid
Melting Point>118°C (dec.)
Molecular Weight421.7
Storage-20°C, Hygroscopic
SolubilityMethanol (Slightly), Water (Slightly)
StabilityVery Hygroscopic
Category Standards; Neurochemicals; Pharmaceutical/API Drug Impurities/Metabolites; Ecgonines/Cocaine Derivatives; Semi-Synthetic;
ApplicationsRTI-55 is a semi-synthetic alkaloid that is a cocaine analogue belonging to the phenyltropane group. RTI-55 acts as a dopamine reuptake inhibitor (DRI) with siginificant abuse potential. RTI-55 is used to assess the rate of dopamine neuron degradation in the brains of patients with ParkinsonтАЩs disease.
ReferencesFujita, M. et al.: J. Chem. Neuroanat., 7, 13 (1994); Elmer, G.I. et al.: Pharmacol. Biochem. Behav., 53, 911 (1996); Coulter, C.L. et al.: Brain Res., 690, 217 (1995);