R124020 Chemical Structure

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R124020

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Product Description

Catalogue NumberR124020
Chemical Name28-O-Methyl-rapamycin
Synonyms23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine Rapamycin Deriv.;
CAS Number159351-88-9
Molecular FormulaC₅₂H₈₁NO₁₃
AppearanceWhite to Off-White Solid
Melting Point>102°C (dec.)
Molecular Weight928.2
Storage-20°C, Hygroscopic
SolubilityDMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
StabilityHygroscopic
Category Research Tools; Chiral Molecules; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications28-O-Methyl-rapamycin is a derivative of Rapamycin (R124000), a triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, RapaтАЩNui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants.
ReferencesMartel, P.R., et al.: Can. J. Physiol. Pharmacol., 55, 48 (1977), Carlson, R.P., et al.: J. Pharmacol. Exp. Ther., 266, 1125 (1993), Kahan, B.D., et al.: Lancet, 356, 194 (2000), Holmes, D.R., et al.: Circulation, 109, 634 (2004),