P840122 Chemical Structure

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2.5mg
$ 205.000.0
25mg
$ 1590.000.0
Exact Weight Packaging
$ 95.000.0
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P840122

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Product Description

Catalogue NumberP840122
Chemical NamePU-H71-d7 Hydrate
Synonyms6-Amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl-d7)-9H-purine-9-propanamine Hydrate;
Alternate CAS #1202865-65-3-unlabelled
Molecular FormulaC₁₈H₁₄D₇IN₆O₃S
Molecular Weight535.41
Category Research Tools;
ApplicationsLabelled PU-H71 (P840122). It is a potent Hsp90 inhibitor (IC50 = 50 nM). Hsp90 plays a critical role in modulating the activity of many cell signaling proteins and are an attractive target for anti-cancer therapeutics. Studies indicate that Hsp90 inhibitors may serve as potential anti-Parkinson′s disease.
ReferencesGewirth, D.T., et al.: J. Med. Chem., 49, 381 (2006), Taldone, T., et al.: Bioorh. Med. Chem., 17, 2225 (2009),