P840120 Chemical Structure

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P840120

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Product Description

Catalogue NumberP840120
Chemical NamePU-H71 Hydrate
Synonyms6-Amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine Hydrate;
CAS Number1202865-65-3
Alternate CAS #Free Base: 873436-91-0
Molecular FormulaC₁₈H₂₁IN₆O₂S • xH₂O
Molecular Weight512.37
Category Research Tools;
ApplicationsPU-H71 is a potent Hsp90 inhibitor (IC50 = 50 nM). Hsp90 plays a critical role in modulating the activity of many cell signaling proteins and are an attractive target for anti-cancer therapeutics. Studies indicate that Hsp90 inhibitors may serve as potential anti-Parkinson′s disease.
ReferencesGewirth, D.T., et al.: J. Med. Chem., 49, 381 (2006), Taldone, T., et al.: Bioorh. Med. Chem., 17, 2225 (2009),