P840110 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
25mg
$ 65.000.0
50mg
$ 125.000.0
100mg
$ 215.000.0
250mg
$ 400.000.0
500mg
$ 760.000.0
1g
$ 1455.000.0
Exact Weight Packaging
$ 95.000.0
Total$ 0.0
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P840110

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Product Description

Catalogue NumberP840110
Chemical NamePteroic Acid (>85%)
Synonyms4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoic Acid; NSC 14972; Pyrofolic acid; p-[(2-Amino-4-hydroxy-6-pteridylmethyl)amino]benzoic Acid; Methotrexate EP Impurity D N-Desmethyl Impurity
ImpurityMethotrexate EP Impurity D N-Desmethyl Impurity
CAS Number119-24-4
Molecular FormulaC₁₄H₁₂N₆O₃
AppearanceLight Yellow to Dark Yellow Solid
Melting Point>300°C (dec.)
Molecular Weight312.28
StorageHygroscopic, -20°C Freezer, Under inert atmosphere
SolubilityAqueous Base (Slightly), DMSO (Slightly)
StabilityHygroscopic
Category Standards; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsPteroic Acid (Methotrexate EP Impurity D N-Desmethyl Impurity) is a constituent as well as a degradation product of Folic Acid (F680300) formed via enzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutamate synthetase.
ReferencesVickers, P.J. et al.: Can. J. Biochem. Cell Biol., 63, 777 (1985): Tafolla, W.H. et al.: J. Pharmac. Sci., 70, 1273 (1981); Iwai, K. et al.: J. Butrit. Sci. Vitaminol., 23, 95 (1977);