Pitavastatin-d5 Lactone

Catalogue number: P531022
Chemical name: Pitavastatin-d5 Lactone
Synonyms: (4R,6S)-6-[(1E)-2-[2-(Cyclopropyl-d5)-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-one; [4R-[4α,6β(E)]]-6-[2-[2-(Cyclopropyl-d5)-4- (4-fluorophenyl)-3-quinolinyl]ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-one; NK 104-d5; NK 104-d5 (lactone); Nisvastatin-d5; P 872441-d5;
Impurity:
CAS Number: NA
Possible CAS #: NA
Molecular form.: C₂₅H₁₇D₅FNO₃
Appearance: White to Pale Yellow Solid
Melting Point: 72-75°C
Mol. Weight: 408.48
Storage: Hygroscopic, -20˚C Freezer, Under Inert Atmosphere
Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
Stability: No Data Available
Category: Aromatics, Chiral Reagents, Inhibitors, Isotope Labelled Compounds, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: A labelled metabolite of Pitavastatin. Recent studies have shown that conversion between acid and lactone forms occurs in the body, drug-drug interaction should be considered on both acid and lactone forms. The inhibitory effects of statins on CYP metabolic activities and MDR1 transporting activity were investigated using human liver microsomes and MDR1-overexpressing LLC-GA5-COL150 cells.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:
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  Pack size Price(USD)
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10mg $4800.00
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Exact Weight Packaging ($75(USD) / Vial)
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Inventory Status:   In Stock



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