P309025 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
10mg
$ 105.000.0
50mg
$ 135.000.0
100mg
$ 185.000.0
250mg
$ 410.000.0
1g
$ 1455.000.0
Exact Weight Packaging
$ 95.000.0
Total$ 0.0
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P309025

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Product Description

Catalogue NumberP309025
Chemical Name((R)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)((S)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)methanone
SynonymsSolifenacin Impurity D
ImpuritySolifenacin EP Impurity D
CAS Number2216750-52-4
Molecular FormulaC₃₁H₂₈N₂O
AppearanceWhite to Off-White Solid
Melting Point180 - 183°C
Molecular Weight444.57
Storage4°C
SolubilityChloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly)
Category Building Blocks; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
Applications((R)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)((S)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)methanone is a possible impurity of solifenacin (S676700) which is a muscarinic M3 receptor antagoinst. Solifenacin is used in treatment of urinary incontinence.
ReferencesIkeda K., et al.: Arch. Pharmacol., 366, 97, (2002); Chapple, C.R., et al.: Br. J. Urol., 93, 303 (2004); Ohtake, A., et al.: Eur. J. Pharmacol., 492, 243 (2004); Brunton, S., et al.: Curr. Med. Res. Opin., 21, 71 (2005); Habb, F., et al.: Eur. Urol. 47, 376 (2005); Payne, C.K., et al.: Drugs, 66, 175 (2006)