Catalogue number: P132000
Chemical name: PAC-1
Synonyms: 4-(Phenylmethyl)-1-piperazineacetic Acid 2-[[2-Hydroxy-3-(2-propen-1-yl)phenyl] methylene]hydrazide; Procaspase Activating Compound 1
CAS Number: 315183-21-2
Possible CAS #: NA
Molecular form.: C₂₃H₂₈N₄O₂
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 392.49
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.
Dangerous Goods Info: NA
Peer Review Product Citations:
MSDS: P132000.pdf

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  Pack size Price(USD)
5mg $55.00
25 mg $85.00
100 mg $305.00
  Pack size Price(USD)
10 mg $70.00
50 mg $160.00
250 mg $675.00

Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   Pending QC

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