NSC 109555
| Catalogue number: | N900530 |
| Chemical name: | NSC 109555 |
| Synonyms: | 4,4’-Diacetyldiphenylurea bis(guanylhydrazone) Bismethanesulfonate; 2,2’-[Carbonylbis(imino-4,1-phenyleneethylidyne)]bis-hydrazinecarboximidamide Dimethanesulfonate |
| Impurity: | |
| CAS Number: | 15427-93-7 |
| Possible CAS #: | NA |
| Molecular form.: | C₂₁H₃₂N₁₀O₇S₂ |
| Appearance: | No Data Available |
| Melting Point: | No Data Available |
| Mol. Weight: | 600.67 |
| Storage: | No Data Available |
| Solubility: | No Data Available |
| Stability: | No Data Available |
| Category: | Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals |
| Boiling Point: | No Data Available |
| Applications: | NSC 109555 is an inhibitor of checkpoint kinase 2 (Chk2), a serine/threonine kinase involved in the ATM-Chk2 checkpoint pathway. Drugs that target Chk2 in combination with DNA-damaging agents can be beneficial in cancer therapy. Studies in mice, rats, rabbits, dogs, and monkeys have shown that NSC 109555 displays toxic effects. A singe injection of the drug at a concentration of 12.5-25 mg/kg caused acute paralysis leading to apnea and death. |
| Dangerous Goods Info: | NA |
| References: | |
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