NSC 109555
Catalogue Number: | N900530 |
Chemical Name: | NSC 109555 |
Synonyms: | 4,4’-Diacetyldiphenylurea bis(guanylhydrazone) Bismethanesulfonate; 2,2’-[Carbonylbis(imino-4,1-phenyleneethylidyne)]bis-hydrazinecarboximidamide Dimethanesulfonate |
CAS Number: | 15427-93-7 |
Molecular Formula: | C₂₁H₃₂N₁₀O₇S₂ |
Molecular Weight: | 600.67 |
Category: | Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals |
Applications: | NSC 109555 is an inhibitor of checkpoint kinase 2 (Chk2), a serine/threonine kinase involved in the ATM-Chk2 checkpoint pathway. Drugs that target Chk2 in combination with DNA-damaging agents can be beneficial in cancer therapy. Studies in mice, rats, rabbits, dogs, and monkeys have shown that NSC 109555 displays toxic effects. A singe injection of the drug at a concentration of 12.5-25 mg/kg caused acute paralysis leading to apnea and death. |
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All Products are stable to be shipped at room temperature, unless otherwise specified. |
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