N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester

Catalogue Number: N497030
Chemical Name: N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester
CAS Number: 1256490-31-9
Molecular Formula: C₁₈H₂₁N₂O₇P
Molecular Weight: 408.34
Solubility: Dichloromethane, Ethyl Acetate, Methanol
Applications: N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2’-deoxy-2’-α-fluoro-β-C-methyluridine-5’-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

All Products are stable to be shipped at room temperature, unless otherwise specified.
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  Pack size Price(USD)
5mg $200.00
25mg $790.00
  Pack size Price(USD)
10mg $350.00

Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   Pending QC

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