N465305 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
250mg
$ 55.000.0
500mg
$ 70.000.0
1g
$ 105.000.0
2.5g
$ 155.000.0
5g
$ 275.000.0
10g
$ 460.000.0
Exact Weight Packaging
$ 95.000.0
Total$ 0.0
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N465305

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Product Description

Catalogue NumberN465305
Chemical Name4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid
CAS Number641569-94-0
Molecular FormulaC₁₇H₁₄N₄O₂
AppearancePale Beige Solid
Melting Point>257ºC (dec.)
Molecular Weight306.32
StorageHygroscopic, Refrigerator, under inert atmosphere
SolubilityDMSO (Slightly), Methanol (Slightly, Heated)
StabilityHygroscopic
Category Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid is used in the preparation of (pyridinyl)-N-[(triazolyl)phenyl]pyrimidinamine derivatives and (pyridinyl)-N-[oxadiazolyl)phenyl]pyrimidinamine derivatives, and can be used in the detection of their activity as antileukemia agents (neoplastic stem cell leukemia). 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid is also a Nilotinib (N465300) intermediate, which might be useful in treatment of chronic myelogenous leukemia.
ReferencesLi, Y., et al.: Bioorg. Med. Chem. Lett., 26, 1419-1427 (2016)