N465302 Chemical Structure

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N465302

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Product Description

Catalogue NumberN465302
Chemical NameNilotinib-d3
Synonyms4-Methyl-N-[3-(4-(methyl-d3)-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide; AMN 107-d3; Tasigna-d3;
CAS Number1215678-43-5
Alternate CAS #unlabelled: 641571-10-0
Molecular FormulaC₂₈H₁₉D₃F₃N₇O
AppearanceOff-White to Pale Yellow Solid
Melting Point227-230°C
Molecular Weight532.53
Storage-20°C Freezer
SolubilityDMSO (Slightly, Heated), Methanol (Slightly, Heated)
Category Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsLabelled analog of Nilotinib (AMN1O7), which might be useful in treatment of chronic myelogenous leukemia. It is a COVID19-related research product.
ReferencesCorbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),