Catalogue number: M755300
Chemical name: (S)-M8-SPy
Synonyms: (α1S,α4S,α7S,2S,5S,8S,11S)-α1,α4,α7,2,5,8,11-Heptamethyl-10-[(1S)-1-methyl-2-oxo-2-[[2-(2-pyridinyldithio)ethyl]amino]ethyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic Acid;
CAS Number: 1192364-56-9
Possible CAS #: NA
Molecular form.: C₃₁H₅₂N₆O₇S₂
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 684.91
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Aromatics, Chiral Reagents, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
Boiling Point: No Data Available
Applications: A new lanthanide chelating tag (M8) for paramagnetic labeling of biomols. is presented, which is based on an eight-fold, stereoselectively methyl-substituted DOTA that can be covalently linked to the host molecule by a single disulfide bond. The steric overcrowding of the DOTA scaffold leads to an extremely rigid, kinetically and chemically inert lanthanide chelator. Due to its exceptionally high stability and lanthanide affinity M8 can be used under extreme chemical or physical conditions, such as those applied for protein denaturation, or when it is undesirable that buffer or protein react with excess lanthanide ions.
Dangerous Goods Info: NA
Peer Review Product Citations:

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