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|Pack Size||Quantity||Price (USD)||Sub Total|
|Exact Weight Packaging||$ 75.00 / Vial||0.0|
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|Chemical Name:||L-Methionine [R,S]-Sulfoximine-13C5|
|Synonyms:||L-S-[3-Amino-3-carboxypropyl]-S-methyl-[R,S]-sulfoximine-13C5; (2S)-2-Amino-4-(S-methylsulfonimidoyl)butanoic Acid-13C5;|
|Alternate CAS #:||15985-39-4 unlabelled|
|Melting Point:||>190°C (dec.)|
|Category:||Research Tools; Amino Acids; Isotopic Labeled Analogues;|
|Applications:||L-Methionine [R,S]-Sulfoximine-13C5,15N is the isotope labelled analog of L-Methionine [R,S]-Sulfoximine. Methionine sulfoximine inhibits both glutamine synthetase and g-glutamylcysteine synthetase. Working concentrations for inhibition of g-glutamylcysteine synthetase are 0.2-2.0 mM (52% inhibition occured at 100 mM).Methionine sulfoximine is also a toxic byproduct of nitrogen trichloride, a compound that was used to bleach unprocessed wheat flour prior to 1968. The compound has been investigated as a potential neurotoxin linked to diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson’s disease.|