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Product Description

Catalogue Number: M260502
Chemical Name: L-Methionine [R,S]-Sulfoximine-13C5
Synonyms: L-S-[3-Amino-3-carboxypropyl]-S-methyl-[R,S]-sulfoximine-13C5; (2S)-2-Amino-4-(S-methylsulfonimidoyl)butanoic Acid-13C5;
Alternate CAS #: 15985-39-4 unlabelled
Molecular Formula: ¹³C₅H₁₂N₂O₃S
Appearance: White Solid
Melting Point: >190°C (dec.)
Molecular Weight: 185.19
Storage: -20°C Freezer
Solubility: Water (Slightly)
Category: Research Tools; Amino Acids; Isotopic Labeled Analogues;
Applications: L-Methionine [R,S]-Sulfoximine-13C5,15N is the isotope labelled analog of L-Methionine [R,S]-Sulfoximine. Methionine sulfoximine inhibits both glutamine synthetase and g-glutamylcysteine synthetase. Working concentrations for inhibition of g-glutamylcysteine synthetase are 0.2-2.0 mM (52% inhibition occured at 100 mM). Methionine sulfoximine is also a toxic byproduct of nitrogen trichloride, a compound that was used to bleach unprocessed wheat flour prior to 1968. The compound has been investigated as a potential neurotoxin linked to diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson’s disease.