M199800 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
5mg
$ 125.000.0
10mg
$ 180.000.0
25mg
$ 305.000.0
100mg
$ 495.000.0
Exact Weight Packaging
$ 75.000.0
Total$ 0.0
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M199800

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Product Description

Catalogue NumberM199800
Chemical NameMDV 3100 (Enzalutamide)
Synonyms4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methylbenzamide; MDV3100; MDV-3100; Enzalutamide;
CAS Number915087-33-1
Molecular FormulaC₂₁H₁₆F₄N₄O₂S
AppearanceWhite to Off-White Solid
Melting Point198 - 200°C
Molecular Weight464.44
StorageRefrigerator
SolubilityChloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
Category Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsMDV 3100 is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer.
ReferencesScher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011);