M199503 Chemical Structure

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Product Description

Catalogue NumberM199503
Chemical NameMCOPPB Trihydrochloride
Synonyms1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazole trihydrochloride; 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazole Hydrochloride (1:3)
CAS Number1108147-88-1
Alternate CAS #Free Base: 1028969-49-4
Molecular FormulaC₂₆H₄₀N₄ • 3(HCl)
Molecular Weight408.62 + 3(36.46)
Category Standards; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsMCOPPB Trihydrochloride is the most potent novel non-peptide NOP full agonist in vitro and an orally potent anxiolytic in the mice. It is the most potent, non-peptide NOP full agonists in vitro and a potent anxiolytic in the mice. It inhibited signaling through the NOP receptor in the mouse brain, suggesting that it penetrated into the brain after it was orally administered. It did not affect locomotor activity or memory, nor did it contribute to ethanol-induced hypnosis.
ReferencesHayashi, S.; et al.: J. Med. Chem., 52, 610 (2009); Hayashi, S. et al.: J. Med. Chem., 52, 610 (2009); Hirao, A. et al.: J . Pharmacol. Sci., 106, 361 (2008);