M199500 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
1mg
$ 50.000.0
5mg
$ 90.000.0
10mg
$ 155.000.0
100mg
$ 1300.000.0
Exact Weight Packaging
$ 95.000.0
Total$ 0.0
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  • Ships On : 5/23/2022
M199500

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Product Description

Catalogue NumberM199500
Chemical NameMCOPPB Trihydrochloride
Synonyms1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazole TriHydrochloride; PF-01678059;
CAS Number1108147-88-1
Alternate CAS #freeamine: 1028969-49-4
Molecular FormulaC₂₆H₄₃Cl₃N₄
AppearanceWhite Solid
Melting Point>249°C (dec.)
Molecular Weight518.01
SolubilityChloroform, Methanol
Category Standards; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsA potent non-peptide nociceptin/orphanin FQ peptide (NOP)-receptor full agonist [or opioid-receptor-like-1 (ORL1) receptor agonist]. It is the most potent, non-peptide NOP full agonists in vitro and a potent anxiolytic in the mice. It inhibited signaling through the NOP receptor in the mouse brain, suggesting that it penetrated into the brain after it was orally administered. It did not affect locomotor activity or memory, nor did it contribute to ethanol-induced hypnosis.
ReferencesHayashi, S. et al.: J. Med. Chem., 52, 610 (2009); Hirao, A. et al.: J . Pharmacol. Sci., 106, 361 (2008);