M156450 Chemical Structure

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Product Description

Catalogue NumberM156450
Chemical NameBenzoic Acid (2Z)-2-(1,2-Dihydro-2-oxo-1-pentyl-3H-indol-3-ylidene)hydrazide
SynonymsMDA-19 Pentyl Analogue
CAS Number1048973-64-3
Alternate CAS #1048973-47-2
Molecular FormulaC20H21N3O2
Molecular Weight335.4
Category Standards; Pharmaceutical/API Drug Impurities/Metabolites; JWH Compounds/Synthetic Cannabinoids;
ApplicationsMDA-19 Pentyl Analogue is an impurity of MDA-19 (H295720), which is a selective agonist of the human peripheral cannabinoid (CB2) receptor. A cell-based functional assay showed MDA is an inverse agonist of the CB2 receptor in rat. Acts as an inverse agonist at the rat CB2 receptor. Reported Ki values are 16.3 and 1130 nM for human CB2 and CB1 receptor respectively. MDA19 was effective in attenuating tactile allodynia in neuropathic rats. MDA19 thus has potential for alleviating neuropathic pain without producing adverse effects in the central nervous system. Synthetic Cannabinoids. MDA-19 Pentyl Analogue can modulate cannabinoid receptors.
ReferencesJijun J. Xu et al. Anesth Analg.111(1): 99–109, (2010); P. Diaz, et al.: J. Med. Chem. 51, 4932 (2008); Attala, M.N., et.al.: U.S. US 8309595 B2, (2012);