Lonafarnib

Catalogue number: L469445
Chemical name: Lonafarnib
Synonyms: 4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide; Sarasar; Sch 66336;
CAS Number: 193275-84-2
Possible CAS #: NA
Molecular form.: C₂₇H₃₁Br₂ClN₄O₂
Appearance: White Solid
Melting Point: 150-152°C
Mol. Weight: 638.82
Storage: Refrigerator
Solubility: Chloroform (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: Lonafarnib is an orally bioavailable tricyclic inhibitor of farnesyl protein transferase. It inhibits Rheb farnesylation and mTOR signaling and enhances taxane and tamoxifen antitumor activity. Studies show that it induces CCAAT/enhancer-binding protein homologous protein-dependent expression of death receptor 5, leading to induction of apoptosis in human cancer cells
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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25mg $410.00
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100mg $1475.00
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Inventory Status:   In Stock

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