L469052 Chemical Structure

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L469052

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Product Description

Catalogue NumberL469052
Chemical Name(+/-)-Lisofylline-d6
Synonyms3,7-Dihydro-1-(5-hydroxyhexyl)-3,7-(dimethyl-d6)-1H-purine-2,6-dione; 1-(5-Hydroxyhexyl)theobromine-d6; (+/-)-1-(5-Hydroxyhexyl)-3,7-(dimethyl-d6) xanthine; BL 194-d6; Pentoxifylline-d6 Alcohol; Hydroxypentoxifylline-d6
CAS Number1185995-26-9
Alternate CAS #6493-06-7-unlabelled
Molecular FormulaC₁₃H₁₄D₆N₄O₃
AppearanceWhite to Off-White Solid
Melting Point125-127°C
Molecular Weight286.36
Storage-20°C Freezer
SolubilityDMSO (Slightly), Methanol (Slightly, Sonicated)
Category Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsA major oxidative labelled metabolite of Pentoxifylline. A potent inhibitor of phosphatidic acid generation (IC50=0.6uM). Protects mice from endotoxic shock and attenuates sepsis-induced acute lung injury in pig.
ReferencesClarke, E., et al.: Cancer Res., et al.: 56, 105 (1996), Itani, S., et al.: Metabolism, 50, 553 (2001), Itani, S., et al.: Diabetes, 51, 2005 (2002), Yu, C., et al.: J. Biol. Chem., 277, 50230 (2002),