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Pack Size | Quantity | Price (USD) | Sub Total |
---|---|---|---|
10mg | $ 8785.00 | 0.0 | |
Exact Weight Packaging | $ 95.00 | 0.0 | |
Total | $ 0.0 |
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L469022
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Product Description
Catalogue Number | L469022 |
Chemical Name | Linsitinib-d3 |
Synonyms | cis-3-[8-Amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-(methyl-d3)cyclobutanol; OSI 906-d3; OSI 906AA-d3; |
Alternate CAS # | unlabelled: 867160-71-2 |
Molecular Formula | C26H20D3N5O |
Molecular Weight | 424.51 |
Category | Standards; Isotopic Labeled Analogues; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
Applications | Labelled Linsitinib (L469020). Linsitinib is a small-molecule dual insulin-like growth factor-1 receptor (IGF-IR) and insulin receptor (IR) kinase inhibitor. IGF-I receptor (IGF-IR) has been implicated in the promotion of tumorigenesis, metastasis and resistance to cancer therapies and thus Linsitinib may be a useful anticancer agent. |
References | Mulvihill, M.M.J. et al.: Fut. Med. Chem., 1, 1153 (2009); Flanigan, S.A. et al.: Clin. Cancer Res., 16, 5436 (2010); McKinley, E.T. et al.: Clin. Cancer Res., 17, 3332 (2011); |