L469020 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
5mg
$ 110.000.0
10mg
$ 235.000.0
50mg
$ 575.000.0
100mg
$ 990.000.0
Exact Weight Packaging
$ 95.000.0
Total$ 0.0
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L469020

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Product Description

Catalogue NumberL469020
Chemical NameLinsitinib
Synonymscis-3-[8-Amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol; OSI 906; OSI 906AA;
CAS Number867160-71-2
Molecular FormulaC₂₆H₂₃N₅O
AppearancePale Yellow to Light Yellow Solid
Melting Point>175°C (dec.)
Molecular Weight421.49
StorageRefrigerator
SolubilityDMSO (Slightly), Methanol (Slightly, Heated)
Category Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsLinsitinib is a small-molecule dual insulin-like growth factor-1 receptor (IGF-IR) and insulin receptor (IR) kinase inhibitor. IGF-I receptor (IGF-IR) has been implicated in the promotion of tumorigenesis, metastasis and resistance to cancer therapies and thus Linsitinib may be a useful anticancer agent. Potent IGF-1R inhibitor.
ReferencesMulvihill, M.M.J. et al.: Fut. Med. Chem., 1, 1153 (2009); Flanigan, S.A. et al.: Clin. Cancer Res., 16, 5436 (2010); McKinley, E.T. et al.: Clin. Cancer Res., 17, 3332 (2011);