Lapaquistat-d9 Acetate


Catalogue number: L175502
Chemical name: Lapaquistat-d9 Acetate
Synonyms: 1-[2-[(3R,5S)-1-[3-(Acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic Acid-d9; (3R-trans)-1-[[1-[3-(acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic Acid-d9; TAK 475-d9;
Impurity:
CAS Number: 1292841-28-1
Possible CAS #: NA
Molecular form.: C₃₃H₃₂D₉ClN₂O₉
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 654.2
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Amines, Chiral Reagents, Heterocycles, Inhibitors, Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: A novel labelled squalene synthase inhibitor. Lapaquistat acetate decreased plasma cholesterol and triglyceride levels, by lowering lipoproteins containing apoB100. Treatment with Lapaquistat acetate increased collagen concentration and transformed coronary plaques into fibromuscular plaques. Lapaquistat acetate also suppressed the expression of matrix metalloproteinase-1 and plasminogen activator inhibitor-1 in the plaque and increased peripheral coenzyme Q10 levels. Antiarteriosclerotics.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:
MSDS: L175502.pdf

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