Lapaquistat Acetate

Catalogue number: L175500
Chemical name: Lapaquistat Acetate
Synonyms: 1-[2-[(3R,5S)-1-[3-(Acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic Acid; (3R-trans)-1-[[1-[3-(acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic Acid; TAK 475;
Impurity:
CAS Number: 189060-13-7
Possible CAS #: NA
Molecular form.: C₃₃H₄₁ClN₂O₉
Appearance: White Solid
Melting Point: >180ºC (dec.)
Mol. Weight: 645.14
Storage: No Data Available
Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Amines, Chiral Reagents, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: A novel squalene synthase inhibitor. Lapaquistat acetate decreased plasma cholesterol and triglyceride levels, by lowering lipoproteins containing apoB100. Treatment with Lapaquistat acetate increased collagen concentration and transformed coronary plaques into fibromuscular plaques. Lapaquistat acetate also suppressed the expression of matrix metalloproteinase-1 and plasminogen activator inhibitor-1 in the plaque and increased peripheral coenzyme Q10 levels. Antiarteriosclerotics.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:
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