K445000 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
5mg
$ 125.000.0
25mg
$ 340.000.0
100mg
$ 995.000.0
Exact Weight Packaging
$ 95.000.0
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  • Ships On : 2/15/2022
K445000

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Product Description

Catalogue NumberK445000
Chemical Name(-)-α-Kainic Acid Monohydrate
Synonyms(2S,3S,4S)-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic Acid Hydrate; [2S-(2α,3β,4β)]-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic Acid Monohydrate
CAS Number58002-62-3
Alternate CAS #Anhydrous: 487-79-6
Molecular FormulaC₁₀H₁₇NO₅
AppearanceWhite Solid
Melting Point>211°C (dec.)
Molecular Weight231.25
SolubilityWater
Category Building Blocks; Miscellaneous;
Applications(-)-α-Kainic Acid Monohydrate is the monohydrated form of (-)-α-Kainic Acid (K135010); a naturally occurring neuroexcitatory chemical that is a selective agonist for a subtype of ionotropic glutamate receptor. Administration of (-)-α-Kainic Acid has been shown to increase production of reactive oxygen species, mitochondrial dysfunction, and apoptosis in neurons in many regions of the brain, particularly in the hippocampal subregions and in the hilus of dentate gyrus.
ReferencesWacker, D.A., et al.: Synlett, 503 (1997); Dunleavy, M., et al.: J. Molec. Neurosci., 49, 202 (2013); Zhang, J., et al.: Neuron., 76, 1133 (2012); Yamada, J., et al.: Neurosci., 226, 119 (2012); Wang,Q., et al.: Mol. Neurobiol., 31, 3 (2005)