K135010 Chemical Structure

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  • Ships On : 9/5/2022

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Product Description

Catalogue NumberK135010
Chemical Name(-)-α-Kainic Acid
Synonyms(2S,3S,4S)-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic Acid; 2-Carboxy-4-isopropenyl-3-pyrrolidineacetic Acid; (-)-Kainic Acid; (2S,3S,4S)-2-Carboxy-4-isopropenylpyrrolidine-3-acetic Acid; Digenic Acid; Digenin; Helminal; Kainic Acid; L-α-Kainic Acid; α-Kainic Acid
CAS Number487-79-6
Molecular FormulaC10H15NO4
AppearanceWhite to Off-White Solid
Melting Point>208°C (dec.)
Molecular Weight213.23
StorageHygroscopic, -20°C Freezer, Under inert atmosphere
SolubilityAqueous Base (Slightly), Methanol (Slightly), Water (Slightly)
Category Standards; Chiral Molecules; Enzyme Activators and Inhibitors; Neurochemicals; Pharmaceutical/API Drug Impurities/Metabolites;
Applications(-)-α-Kainic Acid is a naturally occurring neuroexcitatory chemical that is an selective agonist for a subtype of ionotropic glutamate receptor. Administration of (-)-α-Kainic Acid has been shown to increase production of reactive oxygen species, mitochondrial dysfunction, and apoptosis in neurons in many regions of the brain, particularly in the hippocampal subregions and in the hilus of dentate gyrus.
ReferencesWacker, D.A., et al.: Synlett, 503 (1997), Dunleavy, M., et al.: J. Molec. Neurosci., 49, 202 (2013); Zhang, J., et al.: Neuron., 76, 1133 (2012); Yamada, J., et al.: Neurosci., 226, 119 (2012); Wang,Q., et al.: Mol. Neurobiol., 31, 3 (2005)’