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| Pack Size | Quantity | Price (USD) | Sub Total |
|---|---|---|---|
| 25mg | $ 235.00 | 0.0 | |
| 100mg | $ 770.00 | 0.0 | |
| 200mg | $ 1440.00 | 0.0 | |
| Exact Weight Packaging | $ 95.00 | 0.0 | |
| Total | $ 0.0 | ||
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K135010
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Product Description
| Catalogue Number | K135010 |
| Chemical Name | (-)-α-Kainic Acid |
| Synonyms | (2S,3S,4S)-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic Acid; 2-Carboxy-4-isopropenyl-3-pyrrolidineacetic Acid; (-)-Kainic Acid; (2S,3S,4S)-2-Carboxy-4-isopropenylpyrrolidine-3-acetic Acid; Digenic Acid; Digenin; Helminal; Kainic Acid; L-α-Kainic Acid; α-Kainic Acid |
| CAS Number | 487-79-6 |
| Molecular Formula | C₁₀H₁₅NO₄ |
| Appearance | White to Off-White Solid |
| Melting Point | >208°C (dec.) |
| Molecular Weight | 213.23 |
| Storage | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Solubility | Aqueous Base (Slightly), Methanol (Slightly), Water (Slightly) |
| Category | Standards; Chiral Molecules; Enzyme Activators and Inhibitors; Neurochemicals; Pharmaceutical/API Drug Impurities/Metabolites; |
| Applications | (-)-α-Kainic Acid is a naturally occurring neuroexcitatory chemical that is an selective agonist for a subtype of ionotropic glutamate receptor. Administration of (-)-α-Kainic Acid has been shown to increase production of reactive oxygen species, mitochondrial dysfunction, and apoptosis in neurons in many regions of the brain, particularly in the hippocampal subregions and in the hilus of dentate gyrus. |
| References | Wacker, D.A., et al.: Synlett, 503 (1997), Dunleavy, M., et al.: J. Molec. Neurosci., 49, 202 (2013); Zhang, J., et al.: Neuron., 76, 1133 (2012); Yamada, J., et al.: Neurosci., 226, 119 (2012); Wang,Q., et al.: Mol. Neurobiol., 31, 3 (2005)’ |