1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine, Dihydrochloride


Catalogue Number: I882200
Chemical Name: 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine, Dihydrochloride
Synonyms: HA1077, Fasudil Dihydrochloride;
CAS Number: 203911-27-7
Alternate CAS #: Free Base: 103745-39-7
Molecular Formula: C₁₄H₁₉Cl₂N₃O₂S
Appearance: White to Off-White Solid
Melting Point: >238ºC (dec.)
Molecular Weight: 364.28
Storage: -20°C Freezer
Solubility: Methanol (Slightly), Water (Slightly)
Category: Protein Kinase Inhibitors and Activators
Applications: A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced contraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho-associated Kinase (ROCK IC50= 10.7 uM).
References:

All Products are stable to be shipped at room temperature, unless otherwise specified.
MSDS: I882200.pdf
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  Pack size Price(USD)
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100mg $375.00
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1g $1475.00
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25mg $110.00
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500mg $875.00
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Exact Weight Packaging ($75(USD) / Vial)
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Inventory Status:   In Stock




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