H999750 Chemical Structure

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10mg
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100mg
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H999750

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Product Description

Catalogue NumberH999750
Chemical NameHZ-52
Synonyms2-[[4-([1,1'-biphenyl]-4-ylamino)-6-chloro-2-pyrimidinyl]thio]octanoic Acid; HZ 52;
CAS Number1077626-51-7
Molecular FormulaC₂₄H₂₆ClN₃O₂S
Molecular Weight456
Category Research Tools;
ApplicationsA potent, reversible inhibitor of 5-lipoxygenase, blocking leukotriene synthesis with an IC50 value of 0.7 μM in intact human polymorphonuclear leukocytes. It also attenuates leukotriene B4 synthesis, prevents carrageenan-induced pleurisy, and protects against platelet-activating factor-induced shock in mice when given intraperitoneally.
ReferencesGreiner, C. et al.: Br. J. Pharmacol., 164, 781 (2011); Koeberle, A. et al.: J. Med. Chem., 51, 8068 (2008);