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Pack Size | Quantity | Price (USD) | Sub Total |
---|---|---|---|
10mg | $ 170.00 | 0.0 | |
100mg | $ 1360.00 | 0.0 | |
Exact Weight Packaging | $ 95.00 | 0.0 | |
Total | $ 0.0 |
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H999750
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Product Description
Catalogue Number | H999750 |
Chemical Name | HZ-52 |
Synonyms | 2-[[4-([1,1'-biphenyl]-4-ylamino)-6-chloro-2-pyrimidinyl]thio]octanoic Acid; HZ 52; |
CAS Number | 1077626-51-7 |
Molecular Formula | C₂₄H₂₆ClN₃O₂S |
Molecular Weight | 456 |
Category | Research Tools; |
Applications | A potent, reversible inhibitor of 5-lipoxygenase, blocking leukotriene synthesis with an IC50 value of 0.7 μM in intact human polymorphonuclear leukocytes. It also attenuates leukotriene B4 synthesis, prevents carrageenan-induced pleurisy, and protects against platelet-activating factor-induced shock in mice when given intraperitoneally. |
References | Greiner, C. et al.: Br. J. Pharmacol., 164, 781 (2011); Koeberle, A. et al.: J. Med. Chem., 51, 8068 (2008); |