Hymenialdisine Analogue #1

Catalogue number: H998025
Chemical name: Hymenialdisine Analogue #1
Synonyms: 5-(2-Amino-5-oxo-1,5-dihydroimidazol-4-ylidene)-3,4,5,10-tetrahydro-2H-azepino[3,4-b]indol-1-one
CAS Number: 693222-51-4
Possible CAS #: NA
Molecular form.: C₁₅H₁₃N₅O₂
Appearance: Yellow Solid
Melting Point: >241ºC (dec.)
Mol. Weight: 295.3
Storage: -20˚C Freezer
Solubility: DMSO (Slightly), Methanol (Very Slightly, Heated)
Stability: No Data Available
Category: Protein Kinase Inhibitors and Activators, Tyrosine Kinase Inhibitors
Boiling Point: No Data Available
Applications: The indole derivative of Hymenialdisine, a potent inhibitor of a variety of kinases including MEK-1, GSK-3Β, and CKI. It also exhibits inhibition of the G2 cell cycle checkpoint at the micromolar concentrations. This compound exhibits very potent inhibition of Chk2 activity in the low nanomolar range (IC50=8nM). Exhibits an increased selectivity for the checkpoint kinases over natural Hymenialdisine.
Dangerous Goods Info: NA
Peer Review Product Citations:
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