2’-(R)-Hydroxy-2’,3’-dihydroabacavir Dihydrochloride

Catalogue number: H939485
Chemical name: 2’-(R)-Hydroxy-2’,3’-dihydroabacavir Dihydrochloride
Synonyms: 3-Hydroxy Abacavir
CAS Number: NA
Possible CAS #: NA
Molecular form.: C₁₄H₂₀N₆O₂•2HCl
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 304.357292
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: No Data Available
Boiling Point: No Data Available
Applications: 2’-(R)-Hydroxy-2’,3’dihydroabacavir is the impurity of Abacavir (A104990). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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