H741080 Chemical Structure

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0.5mg
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1mg
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5mg
$ 1405.000.0
10mg
$ 2725.000.0
Exact Weight Packaging
$ 95.000.0
Total$ 0.0
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H741080

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Product Description

Catalogue NumberH741080
Chemical Name3’-Hydroxy-amiodarone Hydrochloride
Synonyms[4-[2-(Diethylamino)ethoxy]-3,5-diiodophenyl][2-(3-hydroxybutyl)-3-benzofuranyl]-methanone Hydrochloride;
CAS Number516508-80-8
Alternate CAS #Free Acid: 725684-62-8
Molecular FormulaC₂₅H₂₉I₂NO₄ • HCl
Molecular Weight661.31 + 36.46
Category Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications3’-Hydroxy-amiodarone Hydrochloride is a metabolite of the drug Amiodarone Hydrochloride (A632950), which is a non-selective ion channel blocker. Antiarrhythmic (class III). Also, it is derived from 4-Pentyn-1-ol (P227540), which is an alkyne alcohol that is used as an initiator in ring-opening polymerization reactions. 4-Pentyn-1-ol is capable of undergoing cyclosisomerization, and is also used as a reactant in the synthesis of (+)-Serinolamide A, a cannabinoid CB1 receptor agonist.
ReferencesBonati, M., et al.: J. Pharm. Sci., 73, 829 (1984), Plomp, T.A., Anal. Profiles Drug Subs., 20, 1 (1991), Chow, M., et al.: Ann. Pharmacother., 30, 637 (1996), Singh, B.N., et al.: Clin. Cardiol., 20, 608 (1997) Gao, Y., et al.: Tetrahedron Lett., 54, 6511 (2013); Liao, R., et al.: Proc. Nat. Acad. Sci., 107, 22523 (2010); Miranda, P., et al.: Org. Lett., 5, 1979 (2003); Xu, N., et al.: Macromol. Chem. Phys., 208, 730 (2007)