GSK 5072 Dihydrochloride

Catalogue number: G797415
Chemical name: GSK 5072 Dihydrochloride
Synonyms: 5-(((4-Chlorobenzyl)(pyridin-3-ylmethyl)amino)methyl)thiophene-2-carbonitrile Dihydrochloride; 5-[[[(4-Chlorophenyl)methyl](3-pyridinylmethyl)amino]methyl]-2-thiophenecarbonitrile Dihydrochloride
CAS Number: NA
Possible CAS #: NA
Molecular form.: C₁₉H₁₆ClN₃S .2HCl
Appearance: Off-White to Pale Yellow Solid
Melting Point: >137ºC (dec.)
Mol. Weight: 353.8736462
Storage: Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility: DMSO (Slightly, Heated), Methanol (Very Slightly, Heated)
Stability: No Data Available
Category: No Data Available
Boiling Point: No Data Available
Applications: GSK 5072 Dihydrochloride, is an analogue of GSK 4112 (G797700) which is a synthetic ligand for REV-ERBα, a member of the nuclear receptor superfamily that functions as a receptor for the porphoryin heme. GSK 4112 mimics the action of heme acting as agonist and suppresses the expression of REV-ERBα target genes involved in gluconeogenesis.
Dangerous Goods Info: NA
Peer Review Product Citations:

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