Genistein-2’,6’-d2
| Catalogue number: | G350005 |
| Chemical name: | Genistein-2’,6’-d2 |
| Synonyms: | 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d2; Baichanin A-d2; Bonistein-d2; 4’,5,7-Trihydroxyisoflavone-d2; GeniVida-d2; Genisteol-d2; NSC 36586-d2; Prunetol-d2; Sophoricol-d2; |
| Impurity: | |
| CAS Number: | 315204-48-9 |
| Possible CAS #: | NA |
| Molecular form.: | C₁₅H₈D₂O₅ |
| Appearance: | Pale Yellow Solid |
| Melting Point: | 304-305°C dec. |
| Mol. Weight: | 272.25 |
| Storage: | -20°C Freezer |
| Solubility: | Acetone, DMSO, Ethyl Acetate |
| Stability: | No Data Available |
| Category: | Inhibitors, Tyrosine Kinase Inhibitors, Isotope Labelled Compounds |
| Boiling Point: | No Data Available |
| Applications: | Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol |
| Dangerous Goods Info: | NA |
| References: | |
| Peer Review Product Citations: | |
| MSDS: | G350005.pdf |
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