Genistein-4,6,2’,3’,5’,6’-d6 Discontinued See G350010

Catalogue number: G350002
Chemical name: Genistein-4,6,2’,3’,5’,6’-d6 Discontinued See G350010
Synonyms: 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d6; Baichanin A-d6; Bonistein-d6; 4’,5,7-Trihydroxyisoflavone-d6; GeniVida-d6; Genisteol-d6; NSC 36586-d6; Prunetol-d6; Sophoricol-d6;
CAS Number: 197657-74-2
Possible CAS #: NA
Molecular form.: C₁₅H₄D₆O₅
Appearance: Light Yellow Solid
Melting Point: No Data Available
Mol. Weight: 276.27
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Inhibitors, Isotope Labelled Compounds, Tyrosine Kinase Inhibitors
Boiling Point: No Data Available
Applications: Labelled Genistein (G350000). Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol
Dangerous Goods Info: NA
Peer Review Product Citations:
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