F844520 Chemical Structure

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Product Description

Catalogue NumberF844520
Chemical NameN-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-N-(2-(6-(((benzhydryloxy)carbonyl)amino)-9H-purin-9-yl)acetyl)glycine
SynonymsN-[2-[6-[[(Diphenylmethoxy)carbonyl]amino]-9H-purin-9-yl]acetyl]-N-[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethyl]glycine; 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(6-(((benzhydryloxy)carbonyl)amino)-9H-purin-9-yl)acetamido)acetic Acid; Fmoc-A-(Bhoc)-OH; Fmoc-PNA-adenine(Bhoc)-OH; Adenine NBHOC AA-FMOC
CAS Number186046-82-2
Alternate CAS #73-24-5
Molecular FormulaC40H35N7O7
Molecular Weight725.75
Category Building Blocks; Nucleic Acid; Amino Acids; Molecular Biology; Amino Acids/Peptides; Nucleic Acids;
ApplicationsN-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-N-(2-(6-(((benzhydryloxy)carbonyl)amino)-9H-purin-9-yl)acetyl)glycine is a peptide nucleic acid (PNA) and can be useful in the detection of circulating microRNA biomarkers from body fluids with application to prostate cancer diagnosis. It can be useful in the study of efficacy of peptide nucleic acid and selected conjugates against specific cellular pathologies of amyotrophic lateral sclerosis. It can also be useful in the study of SNP discrimination by tolane-modified peptide nucleic acids and application for detection of drug resistance in pathogens.
ReferencesMetcalf, G. A. D., et al.: Anal. Chem. (Washington, DC, U. S.), 88, 8091 (2016); Browne, E. C., et al.: Bioorg. Med. Chem., 24, 1520 (2016); Takagi, K., et al.: Molecules, 25, 769 (2020)