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|Pack Size||Quantity||Price (USD)||Sub Total|
|Exact Weight Packaging||$ 95.00||0.0|
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|Chemical Name||Fingolimod Hydrochloride|
|Synonyms||2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol Hydrochloride; FTY720 Hydrochloride;|
|Alternate CAS #||Free Base: 162359-55-9|
|Molecular Formula||C19H33NO2 • HCl|
|Appearance||White to Off-White Solid|
|Melting Point||>106°C (dec.)|
|Molecular Weight||307.48 + (36.46)|
|Solubility||DMSO (Slightly), Methanol (Slightly), Water (Slightly)|
|Category||Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;|
|Applications||Fingolimod Hydrochloride is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. Fingolimod is reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).|
|References||Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),|