F805000 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
5mg
$ 45.000.0
10mg
$ 50.000.0
50mg
$ 80.000.0
100mg
$ 95.000.0
250mg
$ 180.000.0
1g
$ 350.000.0
Exact Weight Packaging
$ 95.000.0
Total$ 0.0
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F805000

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Product Description

Catalogue NumberF805000
Chemical NameFingolimod Hydrochloride
Synonyms2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol Hydrochloride; FTY720 Hydrochloride;
CAS Number162359-56-0
Alternate CAS #Free Base: 162359-55-9
Molecular FormulaC19H33NO2 • HCl
AppearanceWhite to Off-White Solid
Melting Point>106°C (dec.)
Molecular Weight307.48 + (36.46)
Storage-20°C Freezer
SolubilityDMSO (Slightly), Methanol (Slightly), Water (Slightly)
Category Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsFingolimod Hydrochloride is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. Fingolimod is reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
ReferencesBrinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),