5-Fluoroorotic Acid Monohydrate-13C15N2


Catalogue Number: F595002
Chemical Name: 5-Fluoroorotic Acid Monohydrate-13C15N2
Synonyms: 5-FOA-13C15N2
Alternate CAS #: 703-95-7 unlabelled
Molecular Formula: C₄¹³CH₅F¹⁵N₂O₅
Molecular Weight: 195.08
Category: Isotope Labelled Compounds, Nucleotides, Bases & Related Reagents, 5-FOA
Applications: 5-Fluoroorotic Acid Monohydrate-13C15N2 is the isotope analog of 5-Fluoroorotic Acid Monohydrate, (5-FOA). 5-FOA has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5’-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chlo
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