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Product Description

Catalogue Number: F595000
Chemical Name: 5-Fluoroorotic Acid Monohydrate (Ultra Pure)
Synonyms: 5-FOA
CAS Number: 220141-70-8
Alternate CAS #: 703-95-7
Molecular Formula: C₅H₅FN₂O₅
Appearance: Must be White Solid
Melting Point: >255°C (dec.)
Molecular Weight: 192.1
Storage: -20°C Freezer
Solubility: Aqueous Base (Heated), DMSO (Sparingly, Heated), Methanol (Sparingly), Water (Sl
Category: Research Tools; Molecular Biology;
Applications: 5-FOA has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in
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