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|Pack Size||Quantity||Price (USD)||Sub Total|
|Exact Weight Packaging||
||$ 75.00 / Vial||0.0|
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|Chemical Name:||5-Fluoroorotic Acid Monohydrate (Ultra Pure)|
|Alternate CAS #:||703-95-7|
|Appearance:||Must be White Solid|
|Melting Point:||>255°C (dec.)|
|Solubility:||Aqueous Base (Heated), DMSO (Sparingly, Heated), Methanol (Sparingly), Water (Sl|
|Category:||Research Tools; Molecular Biology;|
|Applications:||5-FOA has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in|
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