Have a question about this product Click here.

All Products are stable to be shipped at room temperature, unless otherwise specified.
Pack Size Quantity Price (USD) Sub Total
1g
$ 75.00 0.0
2.5g
$ 150.00 0.0
5g
$ 250.00 0.0
10g
$ 450.00 0.0
25g
$ 950.00 0.0
Exact Weight Packaging
$ 75.00 / Vial 0.0
Total $ 0.0
Request another packsize ? Click here.

Inventory Status : In Stock

Bulk Order Request for F595000

# Pack Size Unit Quantity
1.
2.
3.
4.
5.

Product Description

Catalogue Number: F595000
Chemical Name: 5-Fluoroorotic Acid Monohydrate (Ultra Pure)
Synonyms: 5-FOA
CAS Number: 220141-70-8
Alternate CAS #: 703-95-7
Molecular Formula: C₅H₅FN₂O₅
Appearance: Must be White Solid
Melting Point: >255°C (dec.)
Molecular Weight: 192.1
Storage: -20°C Freezer
Solubility: Aqueous Base (Heated), DMSO (Sparingly, Heated), Methanol (Sparingly), Water (Sl
Category: Research Tools; Molecular Biology;
Applications: 5-FOA has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in
References
Keywords: Buy 220141-70-8 | Purchase 220141-70-8 | Order 220141-70-8 | 220141-70-8 supplier | 220141-70-8 manufacturer | 220141-70-8 distributor | 220141-70-8 cost