E600050 Chemical Structure

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Product Description

Catalogue NumberE600050
Chemical NameErgovaline
Synonyms(5'α)-12'-Hydroxy-2'-methyl-5'-(1-methylethyl)-ergotaman-3',6',18-trione; 8H-Oxazolo[3,2-a]pyrrolo[2,1-c]pyrazine, ergotaman-3',6',18-trione deriv.; 4,6,6a,7,8,9-hexahydro-7-methyl-N-(octahydro-10b-hydroxy-5-isopropyl-2-methyl-3,6-dioxo-8H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)- indolo[4,3-fg]quinoline-9-carboxamide;
CAS Number2873-38-3
Molecular FormulaC₂₉H₃₅N₅O₅
AppearanceLight Beige to Dark Brown Solid
Melting PointN/A
Molecular Weight533.62
StorageHygroscopic, -20°C Freezer, Under inert atmosphere
SolubilityChloroform (Slightly), Methanol (Slightly)
StabilityUnstable in solution
Category Standards; Chiral Molecules; Enzyme Activators and Inhibitors; Neurochemicals; Lysergic Acid Derivatives; Tryptamines;
ApplicationsErgovaline is an ergopetine alkaloid commonly found in endophyte-infected species of tall grass fescue. Ergovaline is known to cause tall fescue toxicosis and is toxic to cattle feeding on the infected grass as it inhibits vesicular glutamate transporter activity in cow cerebral synatic vesicles.
ReferencesXue, Y., et al.: J. Dairy. Sci., 94, 3331 (2011); Najafabdi, A.S., et al.: Res. Pharm. Sci., 5, 135 (2010); Foote, A.P., et al.: J. Animial. Sci., 89, 2944 (2011); Reed, K.F., et al.: Animal. Prod. Sci., 51, 1098 (2011);