E588992 Chemical Structure

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0.5mg
$ 480.000.0
1mg
$ 905.000.0
Exact Weight Packaging
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E588992

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Product Description

Catalogue NumberE588992
Chemical NameEpothilone B-d3 (synthetic)
Synonyms(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione-d3; (-)-Epothilone B-d3; EPO 906-d3; EPO 906A-d3; Epothilone B-d3; Patupilone-d3;
Alternate CAS #152044-54-7
Molecular FormulaC₂₇H₃₈D₃NO₆S
AppearanceWhite to Off-White Solid
Melting Point97-98°C
Molecular Weight510.7
Storage-20°C, Hygroscopic
SolubilityChloroform (Slightly), Methanol (Slightly)
StabilityHygroscopic
Category Standards; Chiral Molecules; Isotopic Labeled Analogues; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsEpothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Isotope labelled Epothilone B is what is known as a microtubule stabilizer. When a cell divides, the chromosomes that will end up in each cell are separated by thin filaments called microtubules. Normally these microtubules then break down as the cell division progresses. This class of cytotoxic chemo drugs prevents that break down and thus prevents cells from completing division.
ReferencesBollag, D.M., et al.: Cancer. Res., 55, 2325 (1995), Hardt, I.H., et al.: J. Nat. Prod., 64, 847 (2001), Gerth, K., et al.: J. Antibiot., 55, 41, 45 (2002)